Grant Support

NIH/NIAID (R21 AI190247), “Defining the role of the Brucella TIR-NAD hydrolase activity in immunosuppression and pathogenesis” (2025-2027).  Smith, MPI

NIH/NIAID & Federal University of Minas Gerais, (R01 AI116453) “Brucella induces STING-mediated guanylate-binding protein expression and unfolded protein response: Balancing bacterial elimination, inflammation and disease” (2021-2026). Smith, Co-Investigator

NIH/NICHD & Northwestern University (R21 HD107571), “Identification of biomarkers for predicting outcomes of COVID-19-related multisystem inflammatory syndrome in children (MISC) using real world clinical data” (2022-2025).  Smith, Co-Investigator

NIH/NIAID, (R21 AI146375) “Unfolded Protein Response (UPR) determinants of Brucella virulence” (2021-2023). Smith, PI

American Lung Association, “Regulation of rhinovirus by the asthma-associated 17q21 locus gene ORMDL3” (2019-2021). Smith, PI

NIH/NIAID & Federal University of Minas Gerais (R01 AI116453), “Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunity,” (2016-2020). Smith, Co-Investigator

UW Office of VCRGE, “Sabotage of host defense mechanisms by Brucella” (2018-2019). Smith, PI

NIH/NIAID (R21 AI121808), “Regulation of human immune function by 17q21 asthma risk polymorphism” (2016-2019). Smith, PI

NIH/NHLBI (P01 HL070831), “COAST – rhinovirus infection and asthma in children and adolescents” (2011-2019). Smith, Project I Co-Investigator

NIH/NIAID (R01 AI073558), “Brucella epitope recognition by CD8+ t cells” (2012-2018). Smith, Co-PI

University of Wisconsin Graduate School, “Immunogenetics of axial spondyloarthritis” (2016-2017). Smith, PI

NIH/NCATS and University of Wisconsin Institute for Clinical and Translational Research (UL1 TR000427), “Development of IL-17 targeting small molecule therapeutics for autoimmune diseases” (2015-2017). Smith, Pilot Grant PI

NIH/NIAID (F31 AI115931), “The role of the unfolded protein response in Brucella melitensis replication” (2014-2017). Smith, Mentor

Rheumatology Research Foundation, “Analysis of causal variants in the IL-23/IL-17 pathway” (2013-2016). Smith, PI

NIH/NIEHS, “Pathogenic studies in families with twins or siblings discordant for systemic rheumatic disorders” (2011-2016). Smith, Site PI

NIH/NIAID and University of Chicago (U54 IA057153), “The role of the host unfolded protein response in Brucella replication” (2013-2014). Smith, Subaward PI

University of Wisconsin Graduate School, “The role of the host unfolded protein response in Brucella replication” (2013-2014). Smith, PI

American College of Rheumatology, “Excess IL-23 production in ankylosing spondylitis and related spondyloarthritides” (2012-2013). Smith, PI

Arthritis National Research Foundation, “Excess IL-23 production and underlying mechanisms in macrophages from ankylosing spondylitis patients” (2011-2012). Smith, PI

University of Wisconsin Graduate School, “The interaction of IFN-beta and endoplasmic reticulum stress in mediating hepatic ischemia reperfusion injury” (2011-2012). Smith, PI

NIH/NIAID (K08 AI081045), “Regulation of IFN-b induction by P2X7 purinergic receptor signaling” (2009-2012). Smith, PI

Novartis, “CACZ885D2306 An open-label, long-term safety and efficacy study of ACZ885 (anti-interleukin-1b monoclonal antibody) administered for at least 6 months in patients with the following cryopyrin-associated periodic syndromes: familial cold autoinflammatory syndrome, muckle-wells syndrome, or neonatal onset multisystem inflammatory disease” (2008-2011). Smith, Site PI

NIH/NCRR & University of Wisconsin Institute for Clinical & Translational Research (UL1 RR025011), “ER stress and cytokine regulation” (2008-2009). Smith, KL2 Scholar

University of Wisconsin Graduate School, “An investigation of the interaction between the unfolded protein response, HLA-B27 and inflammatory cytokine production in macrophages” (2008-2009). Smith, PI

NIH/NCRR & University of Wisconsin Institute for Clinical & Translational Research (UL1 TR025011), “ER Stress and cytokines in ankylosing spondylitis” (2008-2009). Smith, Pilot Grant PI

Arthritis Foundation (post-doctoral fellowship), “HLA-B27 misfolding and cytokine regulation” (2004-2007). Smith, PI